RNA-Seq

Nature Reviews Genetics (doi:10.1038/nrg2484) features a paper titled RNA-Seq: a revolutionary tool for transcriptomics. It is authored by Zhong Wang, Mark Gerstein and Michael Snyder. The paper describes RNA-Seq, an innovative approach to transcriptome profiling which, in the words of the authors, "uses deep-sequencing technologies." The method makes more precise measurement of transcript levels and their isoforms possible. The authors point out that RNA-Seq already has changed our thinking about eukaryotic transcriptomes with respect to their extent and complexity. That should be sobering to those who are so sure that design cannot be found in nature. We've just scratched the surface of knowledge in many fields.