Saturday, January 23, 2010

Impact of Segregation of Chromosomes During Mitosis on Genomic Integrity

Mechanisms of chromosome behaviour during mitosis is a paper authored by Claire E. Walczak, Shang Cai and Alexey Khodjakov which appears in the journal Nature Reviews Molecular Cell Biology. It discusses chromosomes and mitosis as well as genomic fidelity. We would expect to find multiple mechanisms preserving genomic integrity in intelligently sequenced genomes. We are not disappointed.

The behavior, which is the focus of the cited paper, has to do with interactions between chromosomes and spindle microtubules. The interactions are described as highly regulated. The paper contains the following remark:

Recent discoveries, enabled by high-resolution imaging combined with the various genetic, molecular, cell biological and chemical tools, support the idea that establishing and controlling the dynamic interaction between chromosomes and microtubules is a major factor in genomic fidelity.

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