Human Biological Diversity
"Intelligent design begins with a seemingly innocuous question: Can objects, even if nothing is known about how they arose, exhibit features that reliably signal the action of an intelligent cause?"- William Dembski... Then the Lord answered Job from the whirlwind: "Why are you using your ignorance to deny my providence?"- Job38:1-2
Crystal structure of a reverse polymerase is a paper published by PNAS. Its authors are John J. Perona and Javin P. Oza. The first sentence reads: "The primary transcripts of transfer RNA (tRNA) molecules undergo extensive processing and chemical modification to become functional components of the protein synthesis apparatus." Transfer RNA (tRNA) plays a central role in some origin of life scenarios describing how a genetic code might have arisen in a precellular environment. Cells must translate information stored in DNA to enable protein synthesis. Codons correlating to specific amino acids need to be paired and properly sequenced so as to make possible functional sequences of polypeptides. Sets of enzymes known as tRNA synthetases ensure the attachment of a specific amino acid to a specified tRNA.
Labels: Gene Expression
Salvador Cordova wrote Sanford’s pro-ID thesis supported by PNAS paper, read it and weep, literally. Quoting:
Cornell Geneticist John Sanford argued that Darwinism is wrong because the rate of genetic deterioration is so high that natural selection could not arrest it. If natural selection cannot arrest genetic deterioration, how then could it be the mechanism for evolutionary improvement?
Sanford predicted through his research that human genome is deteriorating. This was a daring scientific prediction, and now Michael Lynch of the elite National Academy published on the topic for his inaugural paper. The NAS has now made the paper available to the public free of charge.
Read it, and weep, literally:
the impact of deleterious mutations is accumulating on a time scale that is approximately the same as that for scenarios associated with global warming
My concern, however, is not with mutation as a cause of evolution, but rather as a factor in current and future human welfare. Since most mutations, if they have any effect at all, are harmful, the overall impact of the mutation process must be deleterious. And it is this deleterious effect that I want to discuss.
I conclude that for a number of diseases the mutation rate increases with age and at a rate much faster than linear. This suggests that the greatest mutational health hazard in the human population at present is fertile old males. If males reproduced shortly after puberty (or the equivalent result were attained by early collection of sperm and cold storage for later use) the mutation rate could be greatly reduced.
I am not advocating this.
A more likely reason is that the Chinese want to manufacture the finished goods, thereby creating countless “green” factory jobs, paid for with US and EU taxpayer subsidies, channeled through GE, Siemens, Vestas and other “socially responsible” companies that then install the systems across Europe and the USA.
The Indian government is planning to launch a $11 billion fund to help finance the massive power generation planned during 2012-2017.
Coal remains the backbone of the generation sector in India with more than 55 percent of the power generated by coal-fired power plants
China’s growth has been stellar with high GDP numbers reported yearly. In 2009, Chinese crude oil imports accounted for 52% of the country’s total oil consumption, up from 45% in 2006. Importing more than 50% is recognized as an energy security alert. By 2020, analysts believe that 65% of the oil consumed in China will have to be imported. Not that long ago, China was an oil exporter in 1992.
Which way should we allow it to backfire?
There are many posts at Intelligently Sequenced within the label "DNA Repair." Wikipedia has an article on this topic. This is from it:
In contrast to DNA damage, a mutation is a change in the base sequence of the DNA. A mutation cannot be recognized by enzymes once the base change is present in both DNA strands, and thus a mutation cannot be repaired. At the cellular level, mutations can cause alterations in protein function and regulation. Mutations are replicated when the cell replicates. In a population of cells, mutant cells will increase or decrease in frequency according to the effects of the mutation on the ability of the cell to survive and reproduce. Although distinctly different from each other, DNA damages and mutations are related because DNA damages often cause errors of DNA synthesis during replication or repair and these errors are a major source of mutation.
Given these properties of DNA damage and mutation, it can be seen that DNA damages are a special problem in non-dividing or slowly dividing cells, where unrepaired damages will tend to accumulate over time. On the other hand, in rapidly dividing cells, unrepaired DNA damages that do not kill the cell by blocking replication will tend to cause replication errors and thus mutation. The great majority of mutations that are not neutral in their effect are deleterious to a cell’s survival. Thus, in a population of cells comprising a tissue with replicating cells, mutant cells will tend to be lost. However infrequent mutations that provide a survival advantage will tend to clonally expand at the expense of neighboring cells in the tissue. This advantage to the cell is disadvantageous to the whole organism, because such mutant cells can give rise to cancer. Thus DNA damages in frequently dividing cells, because they give rise to mutations, are a prominent cause of cancer. In contrast, DNA damages in infrequently dividing cells are likely a prominent cause of aging.
Labels: DNA Repair
Eric Hoffer's Skepticism About Darwinism appears at Evolution News and Views. From the article:
He had written that "when God died in the middle of the 19th century there was immediately set in motion a process which tended to reverse the separation of nature and human nature." Darwinism, and the intellectual currents of his day, "aimed to reduce human nature to nature." Biologically, man was now seen as nothing more than "a superior monkey." Politically, he was an automaton who could be manipulated by a Mao or a Stalin.
Hoffer's refusal to join the parade of thinkers who accepted that man was little more than a boastful ape was perhaps his finest hour as a philosopher. It showed him at his most independent. And his perception of the unique qualities of man encouraged him to ponder man's Creator.
Labels: Creation
Androgen-induced TOP2B-mediated double-strand breaks and prostate cancer gene rearrangements, Michael C. Haffner et. al. (Nature Genetics 42, 668–675 (2010)), reminds us that DNA double-strand breaks can induce genomic rearrangements and cancer. The study relates DSBs to androgen signaling.
Labels: DNA Repair
Key Circuits Control Cell's Ability To Adapt To Changes In Its Environment is a Science Daily article. Quoting from it:
ScienceDaily (2009-08-25) -- Researchers have identified the two key circuits that control a cell's ability to adapt to changes in its environment, a finding that could have applications ranging from diabetes and autoimmune research to targeted drug development for complex diseases.
Labels: Adaptation